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Cancer Lett. 2001 Oct 30;172(2):103-9.

Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L.

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Research Institute for Production Development, 15 Shimogamo-Morimoto-cho, Sakyo-ku, 606-0805, Kyoto, Japan.


Capsanthin and related carotenoids isolated from the fruits of red paprika Capsicum annuum L. showed potent in vitro anti-tumor-promoting activity with inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among them, capsanthin diester and capsorbin diester showed strong inhibitory effects. Furthermore, capsanthin , capsanthin 3'-ester and capsanthin 3,3'-diester , major carotenoids in paprika, exhibited potent anti-tumor-promoting activity in an in vivo mouse skin two-stage carcinogenesis assay using 7, 12-dimethylbenz[a]anthracene as an initiator and TPA as a promoter.

[Indexed for MEDLINE]

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