Abstract
A group of genes in the tumour necrosis factor signalling pathway are mutated in humans and mice with ectodermal dysplasias--a failure of hair and tooth development. A mutation has now been identified in one of these genes, ectodysplasin-A receptor, in the teleost fish Medaka, that results in a failure of scale formation.
MeSH terms
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Animals
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Biological Evolution*
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Ectodysplasins
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Edar Receptor
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Fish Proteins / genetics
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Fish Proteins / physiology*
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Hair
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Humans
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Membrane Proteins / genetics
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Mice
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Oryzias
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Tooth
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Tumor Necrosis Factor-alpha / genetics
Substances
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EDA protein, human
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Ectodysplasins
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Eda protein, mouse
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Edar Receptor
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Fish Proteins
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Membrane Proteins
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Tumor Necrosis Factor-alpha
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ectodysplasin-A receptor protein, Oryzias latipes