Fish scale development: Hair today, teeth and scales yesterday?

Curr Biol. 2001 Sep 18;11(18):R751-2. doi: 10.1016/s0960-9822(01)00438-9.

Abstract

A group of genes in the tumour necrosis factor signalling pathway are mutated in humans and mice with ectodermal dysplasias--a failure of hair and tooth development. A mutation has now been identified in one of these genes, ectodysplasin-A receptor, in the teleost fish Medaka, that results in a failure of scale formation.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Biological Evolution*
  • Ectodysplasins
  • Edar Receptor
  • Fish Proteins / genetics
  • Fish Proteins / physiology*
  • Hair
  • Humans
  • Membrane Proteins / genetics
  • Mice
  • Oryzias
  • Tooth
  • Tumor Necrosis Factor-alpha / genetics

Substances

  • EDA protein, human
  • Ectodysplasins
  • Eda protein, mouse
  • Edar Receptor
  • Fish Proteins
  • Membrane Proteins
  • Tumor Necrosis Factor-alpha
  • ectodysplasin-A receptor protein, Oryzias latipes