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Curr Biol. 2001 Sep 18;11(18):R751-2.

Fish scale development: Hair today, teeth and scales yesterday?

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  • 1Department of Craniofacial Development, Floor 28 Guy's Tower, Guy's Hospital, London SE1 9RT, UK.


A group of genes in the tumour necrosis factor signalling pathway are mutated in humans and mice with ectodermal dysplasias--a failure of hair and tooth development. A mutation has now been identified in one of these genes, ectodysplasin-A receptor, in the teleost fish Medaka, that results in a failure of scale formation.

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