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Curr Opin Investig Drugs. 2001 Apr;2(4):558-61.

Application of PNA and LNA oligomers to chemotherapy.

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1
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75390-9041, USA.

Abstract

Peptide nucleic acid (PNA) and locked nucleic acid (LNA) oligomers bind to complementary sequences with extremely high affinity. This high-affinity binding supports the hypothesis that they have advantages for targeting cellular nucleic acids and provide a better route for the development of oligonucleotide-based antiproliferative drugs. This article reviews the properties of PNA and LNA oligomers and describes the challenges that confront their application to cancer therapy.

PMID:
11566018
[Indexed for MEDLINE]
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