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Curr Opin Investig Drugs. 2001 Apr;2(4):496-501.

Inflammatory mediators as therapeutic targets in acute pancreatitis.

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Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, UK.


Multi-organ dysfunction syndrome (MODS) is the primary cause of morbidity and mortality in acute pancreatitis. Recent studies have established the critical role played by inflammatory mediators such as TNFalpha, IL-1beta, IL-6, IL-8, CINC/GROalpha, PAF, IL-10, C5a, ICAM-1 and substance P in acute pancreatitis and the resultant MODS. Potentially, there is a therapeutic window between symptom onset and the development of distant organ damage, when anti-inflammatory therapy may be of use. Elucidation of the key mediators in acute pancreatitis coupled with the discovery of specific inhibitors may make it possible to develop clinically effective anti-inflammatory therapy.

[Indexed for MEDLINE]

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