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Clin Infect Dis. 2001 Oct 15;33(8):1336-40. Epub 2001 Sep 14.

Long-lived immune response to early secretory antigenic target 6 in individuals who had recovered from tuberculosis.

Author information

1
Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC. wuhsiehb@ha.mc.ntu.edu.tw

Abstract

We sought to understand the persistence and relevance of the long-lived immune response to early secretory antigenic target (ESAT-6) of Mycobacterium tuberculosis in humans. ESAT-6 is recognized by memory cells involved in protection of animals against tuberculosis (TB). Recent reports also showed that ESAT-6 response can be recovered in patients with TB and in those soon after anti-TB therapy. We chose 18 individuals who had recovered from pulmonary TB (some in remission for >5 years), and 14 bacille Calmette-Guérin-vaccinated healthy individuals for this study. The results showed that peripheral blood mononuclear cells of 10 (55.6%) of 18 patients with TB remission responded to ESAT-6 with stimulation indices >3.0, whereas none of the healthy controls responded. Functional analysis showed that 13 (72.2%) of 18 patients with TB remission produced significant amounts of IFN-gamma in response to ESAT-6, whereas only 1 (7.1%) of the 14 healthy control subjects did so. It appears that responses to ESAT-6 can persist in individuals who had recovered from pulmonary TB.

PMID:
11565073
DOI:
10.1086/323044
[Indexed for MEDLINE]

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