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Microbes Infect. 2001 Sep;3(11):937-45.

Natural regulatory CD4 T cells expressing CD25.

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Inserm U.345, Institut Necker, 156, rue de Vaugirard, 75730 Paris cedex 15, France.


In normal mice, a subpopulation of CD4 T cells constitutively express CD25. These cells behave as regulatory T cells in autoimmune and inflammatory reactions, in tolerance to superantigens, and in peripheral T-cell homeostasis. They are unable to produce interleukin (IL)-2, and are dependent on IL-2 for growth in vitro and in vivo. CD4 CD25(+) T cells spontaneously secrete IL-10, which is involved in some of their regulatory functions. They are resistant to apoptosis, but can be tolerized by anergy.

[Indexed for MEDLINE]

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