Format

Send to

Choose Destination
Microbes Infect. 2001 Sep;3(11):919-27.

Control of organ-specific autoimmunity by immunoregulatory CD4(+)CD25(+) T cells.

Author information

1
Laboratory of Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

CD4(+)CD25(+) T cells regulate the activity of autoreactive T cells. Depletion of these cells results in the development of a wide-spectrum of organ-specific autoimmune diseases. In vitro model systems have been developed to study the function of these potent suppressor cells. Following their activation via their T-cell receptor, they downregulate the responses of CD25(-) effectors by a T-T interaction.

PMID:
11564440
DOI:
10.1016/s1286-4579(01)01453-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center