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Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):797-9.

Alpha-oligonucleotides with anionic phosphodiester and cationic phosphoramidate linkages enhanced stability of DNA triple helix.

Author information

1
Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-UM II, CC 008, Université Montpellier II, Place Eugène Bataillon, 34095 Montpellier, France.

Abstract

Synthesis of several alpha-oligonucleotides containing both anionic phosphodiester and cationic N-(dimethylaminopropyl)phosphoramidate internucleosidic linkages is described. Their ability to form triple helix with dsDNA was evaluated at various pH by UV melting experiments.

PMID:
11563118
DOI:
10.1081/NCN-100002432
[Indexed for MEDLINE]
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