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Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):669-72.

DNA sequence recognition by NF kappa B p50 homodimer: strict and obscure recognition sites in the binding sequence.

Author information

1
Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199-0195, Japan.

Abstract

5-Formyl- and 5-(formylmethyl)-2'-deoxyuridines are introduced into a kappa B site instead of thymidine(s) in order to understand target sequence specificity of NF kappa B. It was found that one thymidine in the kappa B site is particularly important for the sequence specific recognition by NF kappa B.

PMID:
11563088
DOI:
10.1081/NCN-100002347
[Indexed for MEDLINE]

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