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Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):419-28.

PNA-related oligonucleotide mimics and their evaluation for nucleic acid hybridization studies and analysis.

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1
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, 117871 Moscow, Russia.

Abstract

DNA mimics containing phosphonate analogues of PNAs (pPNAs), particularly PNA-pPNA hybrids as well as hetero-oligomers consisted of pPNA units and PNA-like molecules on the base of trans-4-hydroxy-L-proline (HypNA) have been synthesized. The evaluation of their effectiveness in assays based on the hybridization technique in the comparison with natural oligonucleotides and classical PNAs has shown a high potential of these mimics as sensor molecules for nucleic acid based diagnostics and as molecular probes for mRNA isolation.

PMID:
11563057
DOI:
10.1081/NCN-100002316
[Indexed for MEDLINE]
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