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Virchows Arch. 2001 Aug;439(2):196-200.

Primary intrathoracic meningioma: histopathological, immunohistochemical and ultrastructural study of two cases.

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Department of Pathology, School of Medicine, University of Milan, San Paolo Hospital, Italy.


Meningiomas are common, usually benign slow-growing neoplasms of the central nervous system thought to arise from meningocytes capping arachnoid villi. Primary ectopic meningiomas are exceedingly rare extracranial and extraspinal tumors of controversial origin; they are usually limited to the head and neck region or to the paravertebral soft tissues. Only one mediastinal ectopic meningioma and few pulmonary ectopic meningiomas have been described in the literature until now. Because of their rarity and their intriguing pathogenesis, we report here a second case of primary mediastinal meningioma and an additional case of primary pulmonary meningioma. Their possible origin and differential diagnosis are discussed.

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