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Arch Dermatol. 2001 Sep;137(9):1208-13.

Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation.

Author information

1
Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Abstract

OBJECTIVES:

To determine the efficacy of systemic corticosteroid therapy in treating enlarging, problematic cutaneous hemangiomas and to assess the relationship of dose to response and adverse effects.

DESIGN:

A quantitative systematic literature review was performed and inclusion and exclusion criteria were applied.

SETTING:

Patients were treated in primary care, referral centers, and institutional practices. Most patients were ambulatory, although some required hospitalization.

PATIENTS:

Inclusion criteria were original case series with a minimum of 5 patients with enlarging, problematic cutaneous hemangiomas treated with systemic corticosteroids. Exclusion criteria were being older than 2 years, receiving simultaneous other treatments, being lost to follow-up, or having insufficient information. Twenty-four original case series met inclusion criteria; 10 case series remained (184 patients) after exclusion criteria were applied.

INTERVENTION:

Patients were given a mean prednisone equivalent daily dose of 2.9 mg/kg (95% confidence interval [CI], 2.7-3.1 mg/kg) for a mean of 1.8 months (95% CI, 1.5-2.2 months).

MAIN OUTCOME MEASURES:

Response and rebound rates and dose-response and adverse effects-response relationships in responders vs nonresponders.

RESULTS:

Response was 84% (95% CI, 78%-89%; range, 60%-100%) and rebound was 36% (95% CI, 29%-44%; range, 0%-65%). A significant difference was found between the mean dose administered to responders vs nonresponders (P<.001). No significant difference was observed as to the occurrence of adverse effects (P =.3).

CONCLUSION:

Systemic corticosteroid treatment seems to be effective for problematic cutaneous hemangiomas of infancy.

PMID:
11559219
DOI:
10.1001/archderm.137.9.1208
[Indexed for MEDLINE]

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