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Ultrasound Obstet Gynecol. 2001 Sep;18(3):228-31.

Twin chorionicity and pre-eclampsia.

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Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.



To determine whether the incidence of pre-eclampsia is different in dichorionic compared to monochorionic twin pregnancies.


The study involved 666 twin pregnancies resulting in two live births after 24 weeks of gestation. Ultrasound examination at 10-14 weeks of gestation demonstrated that 171 (25.7%) were monochorionic and 495 (74.3%) were dichorionic twins. Pregnancy outcome information regarding the development of pre-eclampsia was obtained from the maternity units. The incidence of pre-eclampsia in the dichorionic and monochorionic twin pregnancies was compared.


The incidence of pre-eclampsia in monochorionic twin pregnancies (9.4%) was not significantly different from that in dichorionic pregnancies (7.3%) ( P = 0.48). Multiple logistic regression revealed that chorionicity has no effect on the development of pre-eclampsia after adjusting for maternal age, ethnic group, maternal smoking, parity and gestational age at delivery ( P = 0.6; odds ratio for monochorionic compared with dichorionic twin pregnancies, 1.19; 95% confidence interval, 0.61-2.3).


In twin pregnancies chorionicity does not affect the incidence of pre-eclampsia.

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