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Biochem Biophys Res Commun. 2001 Sep 21;287(2):418-21.

Neuroglobins from the zebrafish Danio rerio and the pufferfish Tetraodon nigroviridis.

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Institute of Zoology, Biosafety Research and Consulting, Johannes Gutenberg University of Mainz, M├╝llerweg 6, D-55099 Mainz, Germany.


Neuroglobin is a recently discovered respiratory, porphyrin-containing protein that is expressed in the brain of mouse and man. Here we show that neuroglobin is also present in the teleost fish. Complete cDNA sequences are reported from the pufferfish Tetraodon nigroviridis and the zebrafish Danio rerio. In addition, the neuroglobin gene of T. nigroviridis was sequenced, demonstrating the conservation of the B12.2, E11.0 and G7.0 introns plus the presence of an additional intron in the 5' noncoding region. The fish neuroglobins each comprise 159 amino acids and are 84.3% identical. Phylogenetic analyses show a basal position of the neuroglobins within the metazoan globin tree. An enhanced amino acid substitution rate was estimated for the fish neuroglobins ( approximately 0.93 x 10(-9) amino acid substitutions per site and year) compared with their mammalian proteins ( approximately 0.39 x 10(-9) replacements per site and year).

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