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Trends Endocrinol Metab. 2001 Oct;12(8):366-70.

CO(2)/HCO(3)(-)-responsive soluble adenylyl cyclase as a putative metabolic sensor.

Author information

1
Dept of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

Abstract

Cyclic AMP (cAMP) is an evolutionarily conserved regulator of metabolism. Recently, we identified a novel mammalian source of cAMP - soluble adenylyl cyclase (sAC) - that is regulated directly by bicarbonate ions (HCO(3)(-)). As the concentration of HCO(3)(-) reflects cellular levels of carbon dioxide (CO(2)), energy-generating metabolic processes (which increase intracellular CO(2)) are poised to activate bicarbonate-responsive sAC. This direct link between metabolic activity, sAC and cAMP could represent an evolutionarily conserved mechanism of metabolic feedback regulation.

PMID:
11551811
DOI:
10.1016/s1043-2760(01)00454-4
[Indexed for MEDLINE]

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