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Bioorg Med Chem Lett. 2001 Oct 8;11(19):2627-30.

Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives.

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1
Institut für Organische Chemie, Universität Wien, Währingerstrasse 38, A-1090 Wien, Austria.

Abstract

(E)- and (Z)-5-Desamino huperzine A derivatives have been synthesized using a new synthetic strategy towards the huperzine A skeleton. These derivatives showed AChE inhibition constants in the low micromolar range and thus display better activity than all previously synthesized C5 derivatives.

PMID:
11551765
[Indexed for MEDLINE]

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