Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2001 Oct 8;11(19):2585-8.

Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor.

Author information

1
British Biotech Pharmaceuticals Limited, Watlington Road, Cowley, Oxford OX4 6LY, UK. ayscough@britbio.co.uk

Abstract

By screening a library of metalloenzyme inhibitors, the N-formyl-hydroxylamine derivative BB-3497 was identified as a potent inhibitor of Escherichia coli peptide deformylase with antibacterial activity both in vitro and in vivo. The homochiral synthesis of BB-3497, involving a novel asymmetric Michael addition reaction is described.

PMID:
11551755
DOI:
10.1016/s0960-894x(01)00509-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center