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Pediatr Neurol. 2001 Aug;25(2):166-9.

Cranial MRI changes may precede symptoms in Hallervorden-Spatz syndrome.

Author information

1
Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, OR 97201, USA.

Abstract

Two families are presented in which siblings of children affected with Hallervorden-Spatz syndrome exhibited characteristic cranial magnetic resonance imaging changes before developing clinical features of the disease. Linkage to a major locus on chromosome 20p supported the diagnosis of Hallervorden-Spatz syndrome. In some patients with Hallervorden-Spatz syndrome, iron is radiographically evident before the onset of clinical symptoms.

PMID:
11551748
DOI:
10.1016/s0887-8994(01)00296-x
[Indexed for MEDLINE]

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