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Bioorg Med Chem Lett. 2001 Sep 17;11(18):2521-4.

Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha.

Author information

1
Department of Chemistry, University of Illinois, Urbana, 61801, USA.

Abstract

3-alkyl-2,4,5-triarylfurans with basic side-chain substituents were prepared as ligands for the estrogen receptor. Those analogues having the basic side chain on the C(4) phenol were high-affinity, ERalpha-selective antagonists.

PMID:
11549460
DOI:
10.1016/s0960-894x(01)00488-7
[Indexed for MEDLINE]

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