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Bioorg Med Chem Lett. 2001 Sep 17;11(18):2489-93.

Derivatives of (2R,3R,4S)-2-aminomethylpyrrolidine-3,4-diol are selective alpha-mannosidase inhibitors.

Author information

1
Section de Chimie de l'Université de Lausanne, BCH, CH-1015 Lausanne-Dorigny, Switzerland.

Abstract

A collection of (2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl derivatives have been tested for their inhibitory activities toward 25 glycosidases. Competitive (K(i)=7.4 microM) and selective inhibition of alpha-mannosidase from jack bean has been found for (2R,3R,4S)-2-[(benzylamino)methyl]pyrrolidine-3,4-diol and other derivatives.

PMID:
11549453
[Indexed for MEDLINE]

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