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Biochem Biophys Res Commun. 2001 Sep 14;287(1):277-81.

Molecular model for the binary complex of uropepsin and pepstatin.

Author information

1
Departamento de Física, IBILCE, UNESP, São José do Rio Preto, SP 15054-000, Brazil.

Abstract

The three-dimensional structure of human uropepsin complexed with pepstatin has been modelled using human pepsin as a template. Uropepsin is an aspartic proteinase from the urine, produced in the form of pepsinogen A in the gastric mucosa. The structure is bilobal, consisting of two predominantly beta-sheet lobes which, as observed in other aspartic proteinases, are related by a pseudo twofold axis. A structural comparison between binary complexes of pepsin:pepstatin and uropepsin:pepstatin is discussed.

PMID:
11549287
DOI:
10.1006/bbrc.2001.5555
[Indexed for MEDLINE]

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