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Biochem Biophys Res Commun. 2001 Sep 14;287(1):216-22.

Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene.

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Laboratory of Clinical & Epidemiological Virology, Rega Institute for Medical Research, Minderbroedersstraat 10, BE-3000 Leuven, Belgium.


The human cellular receptor for group B coxsackieviruses and adenoviruses (HCAR) is a transmembrane glycoprotein which belongs to the immunoglobulin superfamily. We describe alternative splicing of the HCAR-gene and the existence of three exon-skipping splice variants in addition to the originally identified seven exon-encompassing mRNA transcript. Expression of the splice variants theoretically results in truncated proteins, possibly leading to impaired viral binding and/or the occurrence of soluble viral receptors due to the absence of the transmembranous region. Consequently, this could markedly influence the efficacy of an adenovirus subgroup C-mediated gene therapy.

[Indexed for MEDLINE]

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