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Nat Prod Lett. 2001;15(1):49-53.

Biotransformation of 1,8-cineole by human liver microsomes.

Author information

  • 1Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka, Osaka 577-8502, Japan.

Abstract

The biotransformation of 1,8-cineole has been investigated by using human liver microsomes. A single oxidized metabolite, 2-exo-hydroxy-1,8-cineole, was isolated. Its formation was investigated under various conditions by changing incubation time, P450 level in liver microsomes, and substrate concentration.

PMID:
11547423
DOI:
10.1080/10575630108041257
[PubMed - indexed for MEDLINE]
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