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Science. 2001 Sep 7;293(5536):1840-2.

Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses.

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1
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA.

Abstract

In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.

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PMID:
11546875
DOI:
10.1126/science.1062882
[Indexed for MEDLINE]
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