Send to

Choose Destination
Neuron. 2001 Aug 30;31(4):519-22.

Stores not just for storage. intracellular calcium release and synaptic plasticity.

Author information

Institute of Physiology, Ludwig-Maximilians University of Munich, 80336 Munich, Germany.


Activation of most excitatory synapses of central neurons produces calcium release signals from intracellular stores. Synaptically evoked calcium release from stores is frequently triggered by the binding of glutamate to metabotropic receptors and the subsequent activation of IP(3) receptors in spines and dendrites. There is increasing evidence for the presence of local calcium signals caused by calcium-induced calcium release (CICR) through activation of ryanodine or IP(3) receptors. Recent work on mutant mice indicates that store signaling determines activity-dependent synaptic plasticity.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center