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Curr Opin Cell Biol. 2001 Oct;13(5):635-40.

Frizzled signaling and cell-cell interactions in planar polarity.

Author information

1
Biology Department and Cancer Center, Gilmer Hall, University of Virginia, Charlottesville, Virginia 22903, USA. pna@virginia.edu

Abstract

The function of the Frizzled pathway is essential for the formation of the array of distally pointing hairs found on the Drosophila wing. Previous research found that regulating the subcellular location for hair initiation controlled hair polarity. Recent work argues a graded Frizzled-dependent signal results in the accumulation of the Frizzled, Dishevelled and Flamingo proteins along the distal edge of the wing cells. This cortical mark leads to the local activation of downstream gene products and the subsequent activation of the cytoskeleton to form a hair.

PMID:
11544034
DOI:
10.1016/s0955-0674(00)00263-5
[Indexed for MEDLINE]

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