Format

Send to

Choose Destination
Curr Opin Cell Biol. 2001 Oct;13(5):584-92.

Assembly and mechanosensory function of focal contacts.

Author information

1
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel. benny.geiger@weizmann.ac.il

Abstract

Focal contacts, focal complexes and related extracellular matrix adhesions are used by cells to explore their environment. These sites act as mechanosensory 'devices', where internal contractile forces or externally applied force can regulate the assembly of the adhesion site and trigger adhesion-dependent signaling involving Rho-family small G-proteins and other signaling pathways. The molecular mechanisms underlying these processes are discussed.

PMID:
11544027
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center