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Helv Chim Acta. 2000 Sep-Oct;83(8):1678-84.

A comparison of RNA with DNA in template-directed synthesis.

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The Salk Institute for Biological Studies, San Diego, CA 92186, USA.
Salk Inst, San Diego, CA
U CA San Diego, La Jolla, CA


Nonenzymatic template-directed copying of RNA sequences rich in cytidylic acid using nucleoside 5'-(2-methylimidazol-1-yl phosphates) as substrates is substantially more efficient than the copying of corresponding DNA sequences. However, many sequences cannot be copied, and the prospect of replication in this system is remote, even for RNA. Surprisingly, wobble-pairing leads to much more efficient incorporation of G opposite U on RNA templates than of G opposite T on DNA templates.

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