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Teratology. 1975 Apr;11(2):219-21.

Teratologic evaluation of imipramine hydrochloride in bonnet (Macaca radiata) and rhesus monkeys (Macaca mulatta).


Imipramine hydrochloride was administered orally twice daily to 18 bonnet and 3 rhesus monkeys between days 23 and 45 of pregnancy for 1-3 or 18-22 days at 1, 2, and 10 times the recommended human dose. No teratologic changes were observed, although signs of maternal toxicity occurred at the high dose level, and the abortion rate was higher than in controls.


The possible teratologic effect of imipramine hydrochloride (IHC) was investigated in pregnanct bonnet and rhesus monkeys. Oral IHC was administered twice daily between Days 23-45 of pregnancy, for either 1-3 days or 18-22 days, at 1, 2, and 10 times the recommended human dose. No teratogenic effects were observed with either acute or chronic treatment. The incidence of early abortion was 9% in the treated groups, compared with 3% in controls. Clinical signs of maternal toxici ty were observed at the high dose level, though symptoms disappeared within 24 hours of the last treatment. It is concluded that the teratogenic potential of IHC is low in humans when used at recommended doses.

[Indexed for MEDLINE]

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