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Europhys Lett. 1998 Aug 15;43(4):363-8.

Stochastic feedback and the regulation of biological rhythms.

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Department of Physics, Boston University, MA 02215, USA.
Beth Israel Hosp, Boston, MA


We propose a general approach to the question of how biological rhythms spontaneously self-regulate, based on the concept of "stochastic feedback". We illustrate this approach by considering at a coarse-grained level the neuroautonomic regulation of the heart rate. The model generates complex dynamics and successfully acounts for key characteristics of cardiac variability, including the l/f power spectrum, the functional form and scaling of the distribution of variations, and correlations in the Fourier phases indicating nonlinear dynamics.

[Indexed for MEDLINE]

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