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Exp Clin Psychopharmacol. 2001 Aug;9(3):277-84.

Haloperiodol-induced microcatalepsy differs in CD-1, BALB/c, and C57BL/6 mice.

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Department of Human Development, Schiefelbusch Institute for Life Span Studies, University of Kansas, Lawrence 66045, USA.


The degree of arrest of movement (microcatalepsy) induced by haloperidol at doses equipotent for operant rate suppression was measured with computerized instrumentation. The inbred C57BL/6 mouse strain displayed more susceptibility to microcatalepsy than the CD-1 and BALB/c strains. In addition, the C57BL/6 strain exhibited a greater degree of sensitization to repeated dosing than did the other 2 strains. The results were consistent with the C57BL/6 mouse's hypodopaminergic profile reported in the literature but were at odds with results reported for conventional catalepsy testing. The C57BL/6 mouse may serve as a model for genetic vulnerability to extrapyramidal motor side effects and may be useful in quantifying the mild extrapyramidal motor side effects of atypical antipsychotic drugs.

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