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Nat Rev Mol Cell Biol. 2001 Sep;2(9):688-98.

Re-evaluating centrosome function.

Author information

1
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA. stephen.doxsey@umassmed.edu

Abstract

Over the past 100 years, the centrosome has risen in status from an enigmatic organelle, located at the focus of microtubules, to a key player in cell-cycle progression and cellular control. A growing body of evidence indicates that centrosomes might not be essential for spindle assembly, whereas recent data indicate that they might be important for initiating S phase and completing cytokinesis. Molecules that regulate centrosome duplication have been identified, and the expanding list of intriguing centrosome-anchored activities, the functions of which have yet to be determined, promises continued discovery.

PMID:
11533726
DOI:
10.1038/35089575
[Indexed for MEDLINE]

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