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Nat Cell Biol. 2001 Sep;3(9):E209-11.

EGF receptors as transcription factors: ridiculous or sublime?

Author information

1
Centre for Molecular Cell Biology, Department of Medicine, Royal Free and University College Medical School, Royal Free Campus, Hampstead, London, NW3 2PF, UK. m.waugh@rfc.ucl.ac.uk

Abstract

The notion that a transmembrane receptor at the cell surface can somehow reappear as a transcription factor in the nucleus is bound to be controversial. However, there are two reported examples of this. If this hypothesis can withstand the inevitable and necessary battery of additional empirical tests, then our understanding of signal transduction needs to move in a new direction.

PMID:
11533675
DOI:
10.1038/ncb0901-e209
[Indexed for MEDLINE]

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