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J Affect Disord. 2001 Sep;66(1):89-93.

S-100B is increased in melancholic but not in non-melancholic major depression.

Author information

1
Department of Psychiatry, University of Muenster, Albert-Schweitzer-Str. 11, D-48129 Muenster, Germany. rothermu@uni-muenster.de

Abstract

BACKGROUND:

Recent evidence suggests that neurodegeneration may be involved in the pathophysiology of major depression. The astroglial peptide S-100B was shown to be increased in many diseases causing neuronal cell damage or degeneration.

METHOD:

S-100B plasma levels were determined in 28 patients with major depression and 28 matched healthy controls using an immunofluorometric sandwich assay.

RESULTS:

Patients suffering from melancholic depression showed significantly increased S-100B levels compared to healthy controls while non-melancholic patients demonstrated normal levels.

LIMITATIONS:

Medication of patients varied. The differentiation between melancholic and non-melancholic patients was performed clinically without using a standardized instrument.

CONCLUSIONS:

Neurodegeneration or axonal remodeling may be involved in the pathogenesis of melancholic depression.

PMID:
11532538
[Indexed for MEDLINE]

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