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Fertil Steril. 2001 Sep;76(3):615-7.

Relationship between salivary progesterone, 17-hydroxyprogesterone, and cortisol levels throughout the normal menstrual cycle of healthy postmenarcheal girls.

Author information

1
Klinik mit Poliklinik für Kinder und Jugendliche, Friedrich-Alexander-University, Erlangen-Nürnberg, Germany. michael.groeschl@kinder.imed.uni-erlangen.de

Abstract

OBJECTIVE:

To determine the usefulness of salivary P and 17 alpha-hydroxyprogesterone (17-OHP) for the assessment of ovarian function. In addition, salivary cortisol (F) levels were measured to assess the role of the adrenal cortex throughout the menstrual cycle.

DESIGN:

Prospective study.

SETTING:

Outpatients in hospital for children and adolescents.

PATIENT(S):

Thirty young women with regular menstrual cycles.

INTERVENTION(S):

Saliva collection in the early morning from day 1 of menstrual bleeding until next menses.

MAIN OUTCOME MEASURE(S):

Salivary P, 17-OHP, and F measured by RIAs.

RESULT(S):

During days 1-12 of the follicular phase, P and 17-OHP levels remained unchanged (P: 9-29.3 pg/mL; 17-OHP: 8-31 pg/mL). Thereafter, P increased exponentially from day 13 onward, reaching a plateau (mean +/- SEM, 70.1 +/- 9.0 pg/mL) between day 16 and 20, followed by a constant decrease until end of the cycle. The 17-OHP levels increased between day 14 and 17 (maximum: 45.8 +/- 4.5 pg/mL), decreasing rapidly thereafter. The F levels remained unchanged (follicular: 7.5 +/- 1.1 ng/mL; luteal 7.2 +/- 1.1 ng/mL). There was a significant correlation between P and 17-OHP (r(2) = 0.43; P<.001). When calculating ratios of P/F and 17-OHP/F, linear regression yielded a much stronger correlation (r(2) = 0.74; P<.001), although F did not show any correlation to P or 17-OHP.

CONCLUSION(S):

Changes in salivary 17-OHP levels throughout the menstrual cycle reflect ovarian but not adrenal function.

PMID:
11532491
DOI:
10.1016/s0015-0282(01)01960-4
[Indexed for MEDLINE]

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