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FEBS Lett. 2001 Aug 31;504(3):118-25.

Neuronal nicotinic receptors: from protein structure to function.

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Department of Physiology, CMU, 1 rue Michel Servet, CH-1211, Geneva 4, Switzerland.


Neuronal nicotinic acetylcholine receptors are a prototype of ligand-gated channels that mediate transmission in the central and peripheral nervous system. Structure-function studies performed at the amino acid level are now unraveling the determinant residues either for the properties of the ligand-binding domain or the ionic pore. In this work we review, in the light of the latest finding, the structure-function relationship of these receptors and their implication in neurological diseases.

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