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Brain Res. 2001 Sep 14;913(1):86-9.

Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy.

Author information

1
Neurologische Klinik der Universität Würzburg, Josef-Schneider-Strasse 11, 97080 Würzburg, Germany. sommer@mail.uni-wuerzburg.de

Abstract

We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-alpha (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment.

PMID:
11532251
DOI:
10.1016/s0006-8993(01)02743-3
[Indexed for MEDLINE]

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