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Gynecol Oncol. 2001 Aug;82(2):269-72.

Low incidence of HPV DNA in sera of pretreatment cervical cancer patients.

Author information

1
Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong.

Abstract

OBJECTIVE:

The aim of this study was to investigate the feasibility of using DNA in the circulation as a diagnostic tool for cervical cancer.

METHODS:

We used PCR followed by Southern hybridization to detect human papillomavirus (HPV) DNA in serum samples taken from patients of cervical cancer before treatment.

RESULTS:

A total of 60 samples were analyzed. In a set of 40 samples, without knowledge of the HPV DNA status in the corresponding cervical carcinomas, we could detect 8 (20%) positive samples, of which 7 (17.5%) were HPV 16 and 1 (2.5%) was HPV 18. In another set of 20 samples, known to be HPV 16 infected in the corresponding cervical carcinomas, we detected only 4 (20%) HPV-16-positive samples. The occurrence of HPV DNA in sera of cervical cancer patients seems sporadic.

CONCLUSION:

The low incidence indicates that serum HPV DNA has limited application in the diagnosis of cervical cancer.

PMID:
11531278
DOI:
10.1006/gyno.2001.6289
[Indexed for MEDLINE]

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