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Bioorg Med Chem Lett. 2001 Sep 3;11(17):2279-82.

Design and synthesis of glycolic and mandelic acid derivatives as factor Xa inhibitors.

Author information

1
COR Therapeutics, Inc., 256 East Grand Avenue, South San Francisco, CA 94080, USA. tsu@corr.com

Abstract

A series of glycolic and mandelic acid derivatives was synthesized and investigated for their factor Xa inhibitory activity. These analogues are highly potent and selective inhibitors against fXa. In a rabbit deep vein thrombosis model, compound 26 showed significant antithrombotic effects (81% inhibition of thrombus formation) at 1.1 microM plasma concentration following intravenous administration.

PMID:
11527714
DOI:
10.1016/s0960-894x(01)00447-4
[Indexed for MEDLINE]

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