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Bioorg Med Chem Lett. 2001 Sep 3;11(17):2229-34.

Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues.

Author information

1
Janssen Research Foundation, Welsh and McKean Roads, Spring House, PA 19477, USA.

Abstract

A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs. The synthesis and anti-HIV structure-activity relationship (SAR) studies of a series of DATA derivatives are described.

PMID:
11527704
DOI:
10.1016/s0960-894x(01)00411-5
[Indexed for MEDLINE]

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