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Biophys Chem. 2001 Aug 30;92(1-2):119-26.

Protection of radiation-induced protein damage by curcumin.

Author information

1
Radiation Chemistry and Chemical Dynamics Division, Bhabha Atomic Research Center, Mumbai 400 085, India. sudhirk@apsara.barc.ernet.in

Abstract

Free radical reactions of lysozyme (Lz), tryptophan and disulfides were studied with curcumin, a lipid-soluble antioxidant from turmeric, in aqueous solution using a pulse radiolysis technique. The binding of curcumin with lysozyme was confirmed using absorption, fluorescence and stopped-flow techniques. The free radicals of curcumin generated after repairing radicals of disulfides, lysozyme and tryptophan absorb at 500-510 nm. Implication of this in evaluating the antioxidant behavior of curcumin in protecting proteins is discussed.

PMID:
11527584
DOI:
10.1016/s0301-4622(01)00188-0
[Indexed for MEDLINE]

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