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Nat Immunol. 2001 Sep;2(9):842-7.

Deletion of a coordinate regulator of type 2 cytokine expression in mice.

Author information

1
Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA.

Abstract

Mechanisms that underlie the patterning of cytokine expression in T helper (T(H)) cell subsets remain incompletely defined. An evolutionarily conserved approximately 400-bp noncoding sequence in the intergenic region between the genes Il4 and Il13, designated conserved noncoding sequence 1 (CNS-1), was deleted in mice. The capacity to develop T(H)2 cells was compromised in vitro and in vivo in the absence of CNS-1. Despite the profound effect in T cells, mast cells from CNS-1(-/-) mice maintained their capacity to produce interleukin 4. A T cell-specific element critical for the optimal expression of type 2 cytokines may represent the evolution of a regulatory sequence exploited by adaptive immunity.

PMID:
11526400
DOI:
10.1038/ni0901-842
[Indexed for MEDLINE]

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