Format

Send to

Choose Destination
Nat Immunol. 2001 Sep;2(9):810-5.

Tolerogenic strategies to halt or prevent type 1 diabetes.

Author information

1
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. ac@mole.bio.cam.ac.uk

Abstract

A variety of therapeutic strategies have been developed to tolerize autoreactive T cells and prevent autoimmune pathology. In terms of type 1 diabetes, prevention strategies can inhibit the priming and expansion of autoreactive T cells; however, a cure for diabetes would require tolerance to be established in the presence of primed effector cells together with replacement of the destroyed beta cell mass. Replacement of beta cells could be accomplished by transplantation of islets or stem cells or through islet regeneration. We will focus here on tolerogenic strategies that have been used to prevent onset of type 1 diabetes and discuss the potential for a cure.

PMID:
11526391
DOI:
10.1038/ni0901-810
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center