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Trends Genet. 2001 Sep;17(9):511-9.

PDZ proteins and polarity: functions from the fly.

Author information

1
Dept of Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA. bilder@rascal.med.havard.edu

Abstract

Proteins that contain PDZ domains have been implicated in the localization of interacting partners to specific regions of the cell membrane. Although PDZ proteins that bind to a number of important mammalian proteins have been isolated, the significance of these interactions is unclear. In recent years, the fruit fly has emerged as a rich system for genetic analysis of PDZ protein function. Here, I discuss what the Drosophila data tell us about the roles and mechanisms of PDZ protein activity, and how this informs our understanding of PDZ function in other organisms.

PMID:
11525834
DOI:
10.1016/s0168-9525(01)02407-6
[Indexed for MEDLINE]

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