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Trends Genet. 2001 Sep;17(9):511-9.

PDZ proteins and polarity: functions from the fly.

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Dept of Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA.


Proteins that contain PDZ domains have been implicated in the localization of interacting partners to specific regions of the cell membrane. Although PDZ proteins that bind to a number of important mammalian proteins have been isolated, the significance of these interactions is unclear. In recent years, the fruit fly has emerged as a rich system for genetic analysis of PDZ protein function. Here, I discuss what the Drosophila data tell us about the roles and mechanisms of PDZ protein activity, and how this informs our understanding of PDZ function in other organisms.

[Indexed for MEDLINE]

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