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Nihon Ronen Igakkai Zasshi. 2001 Jul;38(4):440-3.

[Defensins as a mechanism of host defense and innate immunity].

[Article in Japanese]

Author information

1
Department of Geriatric Medicine, Faculty of Medicine, University of Tokyo.

Abstract

Antimicrobial peptides, including beta-defensins, are thought to be effective agents against opportunistic infections. In humans, three beta-defensins have been identified. The first human beta-defensin, hBD-1, is predominantly expressed in epithelia of the urogenital tract and has been reported to be constitutive. The second and third human beta-defensins, hBD-2 and hBD-3, were isolated from psoriatic skin and found to be predominantly expressed in skin and respiratory tract. Of note, the hBD-2 gene expression is inducible by various proinflammatory agents such as TNF-alpha, IL-1 beta, IL-8, LPS, bacteria, and yeasts. It has been shown that LPS-induced expression of hBD-2 in human tracheobronchial epithelial cells requires CD14, which may complex with Toll-like receptors (TLRs) to ultimately activate NF-kappa B. In addition, beta-defensins have been recently reported to promote immune responses by recruiting dendritic and T cells. Defensins may play a key role in the mechanism of host defense and innate immunity. These defensins, including hBD-2, might provide a new therapeutic approach to infectious diseases.

PMID:
11523142
DOI:
10.3143/geriatrics.38.440
[Indexed for MEDLINE]
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