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Science. 2001 Oct 12;294(5541):361-4. Epub 2001 Aug 23.

Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin.

Author information

1
Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.

Abstract

Small molecules that affect specific protein functions can be valuable tools for dissecting complex cellular processes. Peptidoglycan synthesis and degradation is a process in bacteria that involves multiple enzymes under strict temporal and spatial regulation. We used a set of small molecules that inhibit the transglycosylation step of peptidoglycan synthesis to discover genes that help to regulate this process. We identified a gene responsible for the susceptibility of Escherichia coli cells to killing by glycolipid derivatives of vancomycin, thus establishing a genetic basis for activity differences between these compounds and vancomycin.

PMID:
11520949
DOI:
10.1126/science.1063611
[Indexed for MEDLINE]
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