Send to

Choose Destination
Cancer Genet Cytogenet. 2001 Aug;129(1):47-51.

Comparative genomic hybridization reveals non-random chromosomal aberrations in early preinvasive cervical lesions.

Author information

Cytogenetic Laboratory, Department of Clinical Genetics, Juliane Marie Center, The National University Hospital, Copenhagen, Denmark.


We performed CGH analysis on 34 cervical lesions, which included 8 cases of koilocytosis, 6 mild dysplasias and 20 moderate dysplasias. Chromosome aberrations were detected in 11 cases of which 9 were moderate dysplasias. A total of 55 chromosome arms were involved. The most frequent aberrations were losses of 5p and Xq, each of which was present in 5/34 cases. Gain of 3q was detected in two moderate dysplasias. This aberration is the most frequent copy number change in advanced-stage cervical carcinoma. A considerable number of the aberrations found in the preinvasive cases of this study are frequently present in invasive cervical tumors. The presence of apparently non-random chromosome aberrations in early preinvasive cervical lesions has not previously been described.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center