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Cancer Genet Cytogenet. 2001 Aug;129(1):47-51.

Comparative genomic hybridization reveals non-random chromosomal aberrations in early preinvasive cervical lesions.

Author information

1
Cytogenetic Laboratory, Department of Clinical Genetics, Juliane Marie Center, The National University Hospital, Copenhagen, Denmark. markir@rh.dk

Abstract

We performed CGH analysis on 34 cervical lesions, which included 8 cases of koilocytosis, 6 mild dysplasias and 20 moderate dysplasias. Chromosome aberrations were detected in 11 cases of which 9 were moderate dysplasias. A total of 55 chromosome arms were involved. The most frequent aberrations were losses of 5p and Xq, each of which was present in 5/34 cases. Gain of 3q was detected in two moderate dysplasias. This aberration is the most frequent copy number change in advanced-stage cervical carcinoma. A considerable number of the aberrations found in the preinvasive cases of this study are frequently present in invasive cervical tumors. The presence of apparently non-random chromosome aberrations in early preinvasive cervical lesions has not previously been described.

PMID:
11520566
DOI:
10.1016/s0165-4608(01)00424-1
[Indexed for MEDLINE]

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