A novel modified pterin from a Eudistoma species ascidian

J Nat Prod. 2001 Aug;64(8):1100-1. doi: 10.1021/np010127h.

Abstract

The MeOH extract of an Indonesia Eudistoma sp. ascidian contained 1,3,O(7)-trimethylisoxanthopterin (1), a novel pteridine. The purification of 1 was achieved through flash C(18) chromatography and cyano HPLC. The structure was determined primarily through the use of (1)H-(13)C and (1)H-(15)N HMBC measurements and comparison with data obtained for 1,3,7-trimethylguanine (2).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromatography, High Pressure Liquid
  • Gas Chromatography-Mass Spectrometry
  • Guanine / analogs & derivatives
  • Guanine / chemistry
  • Guanine / isolation & purification*
  • Guanine / pharmacology
  • Indonesia
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Pterins / chemistry
  • Pterins / isolation & purification*
  • Pterins / pharmacology
  • Spectrophotometry, Ultraviolet
  • Spectroscopy, Fourier Transform Infrared
  • Urochordata / chemistry*

Substances

  • 1,3,7-trimethylguanine
  • 1,3,O(7)-trimethylisoxanthopterin
  • Pterins
  • Guanine