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J Neurovirol. 2001 Apr;7(2):155-62.

CD4/CXCR4-independent infection of human astrocytes by a T-tropic strain of HIV-1.

Author information

1
Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island 02192, USA.

Abstract

HIV-1 establishes a low-level persistent infection in astrocytes. In this study, we studied the susceptibility of a human astrocyte cell line (SVG-A) to infection with luciferase expressing reporter viruses pseudotyped with envelopes derived from five isolates of HIV-1. SVG-A cells were susceptible to infection by a T-cell tropic isolate and the infection was both CD4 and CXCR4 independent. These data confirm the susceptibility of astrocytes to infection with T-tropic strains of HIV-1 and suggest a novel mechanism by which T-tropic strains of HIV can infect cells.

PMID:
11517388
DOI:
10.1080/13550280152058816
[Indexed for MEDLINE]

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