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Trends Mol Med. 2001 Aug;7(8):355-62.

The calpain family and human disease.

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Laboratory of Neuro-biochemistry, Dept. of CNS Molecular Sciences, Pfizer Global Research & Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA.


The number of mammalian calpain protease family members has grown to 14 on last count. Overactivation of calpain 1 and calpain 2 (and their small subunit) has long been tied to acute neurological disorders (e.g. stroke and traumatic brain injury) and recently to Alzheimer's disease. Loss-of-function mutations of the calpain 3 gene have now been identified as the cause of limb-girdle muscular dystrophy 2A. Calpain 10 was recently identified as a susceptibility gene for type 2 diabetes, whereas calpain 9 appears to be a gastric cancer suppressor. This review describes our current understanding of the calpain family members and their mechanistic linkages to the aforementioned diseases as well as other emerging pathological conditions.

[Indexed for MEDLINE]

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